Sacubitril Hemicalcium

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Sacubitril Hemicalcium   I-Roto      

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    库 比 曲 半 钙盐 Sacubitril Hemicalcium 1369773-39-6 I-Roto
    库 比 曲 钠盐 149690-05-1 I-Roto
    LCZ-4 1426129-50-1 I-Roto
    LCZ-7 1012341-48-8 I-Roto
    LCZ-8 1012341-50-2 I-Roto
    LCZ-9 149690-12-0 I-Roto

 

Papamuri

AHU-377 te tote hemicalcium he momo tote hemicalcium o te AHU-377. He aukati i te neprilysin me te uara IC50 o te 5 nM [1].

Ko te AHU-377 me te angiotensin II AT1 kaiwhiwhi kaitaakiri valsartan tito LCZ696 i te tauwehenga molar 1: 1. Ko te LCZ696 he kaipupuri i te kaipupuri neprilysin hei kaiwhiwhi. Ka taea te whakaheke i te toto toto ka waiho pea hei rongoa hou hei whakaora i te ngoikore o te ngakau. Ko te AHU-377 he rongoa rongoa, ka taea te huri na te wehenga enzymatic o te ether ester ki roto i te LBQ657 puka hohe. E kiia ana ko te AHU-377 (30 me te 100 mg / kg, PO) ka pa ki te mate antihypertensive i runga i te tikanga horopeta-kiore i nga kiore DAHI-SS Engari i roto i nga kiore whakaheke toto-DOCA-tote, e whakaatu ana i te whakahekenga ngoikore [2, 3].

Tohutoro:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide kūpapa endopeptidase aukati. J Med Chem. 1995 Mei 12; 38 (10): 1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Ko te mahi pea a valsartan + AHU377 (LCZ696) ki te whakaora i te ngoikore o te ngakau. Tohunga Opin Investig Drugs. 2013 Akuhata; 22 (8): 1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al. Te kaha whakataurite o te AHU-377, he kaipupuri neprilysin puai, i roto i nga tauira e rua o te kiore o te takawhita-tiimata BMC Pharmacology 2011, 11 (Taputapu 1): P33.

Hanganga matū

Sacubitril Hemicalcium

WHAKAMAHI

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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