Bictegravir 1611493-60-7

Whakaahuatanga Poto:

Ingoa API Tohutohu Kaihanga hou Te Ra Whakamutunga Patent(Te US)
Bictegravir 1611493-60-7 Te mate HIV-1 Pūtaiao Gileada Tihema 19, 2033


Taipitopito Hua

Tohu Hua

WHAKAMAHI HUA

Whakaahuatanga

Ko Bictegravir he pukapuka, he aukati kaha o te whakauru HIV-1 me te IC50 o te 7.5 nM.

In Vitro

Ko te Bictegravir (BIC) te aukati i te mahi whakawhiti whenu me te IC50 o 7.5± 0.3 nM.E pa ana ki tana aukati i nga mahi whakawhiti whenu, ko te Bictegravir he aukati ngoikore o te 3'- mahi tukatuka o HIV-1 IN, me te IC50 o 241±51 nM.Ka whakanui a Bictegravir i te kohinga o nga porowhita 2-LTR ~5-fold e pa ana ki te mana whakahiahia me te whakaiti i te nui o nga hua whakauru pono i roto i nga pūtau pangia e te 100-fold.Ka kaha te aukati a Bictegravir i te tukuruatanga HIV-1 i roto i nga pūtau MT-2 me MT-4 me nga EC50 o te 1.5 me te 2.4 nM, ia.Ko te Bictegravir e whakaatu ana i nga paanga antiviral kaha i roto i nga lymphocytes CD4+ T tuatahi me nga macrophages i ahu mai i te monocyte, me nga EC50 o te 1.5±0.3 nM me te 6.6±4.1 nM, ia, e rite ana ki nga uara e whiwhi ana i nga rarangi T-cell[1].

Kare ano a MCE i whakapumau takitahi i te tika o enei tikanga.He tohutoro anake.

Nama NCT Kaitautoko Tikanga Rā Tīmata

Wāhanga

NCT03998176 Te Whare Wananga o Nebraska|Gilead Sciences HIV-1-mate Oketopa 9, 2019

Wāhanga 4

NCT03789968 Te Whare Wananga o Thomas Jefferson|Te Whare Wananga o Maryland, College Park|Te Whare Wananga o Indiana|Te Whare Wananga o te Whare Wananga o Brooklyn|Te Whare Wananga o Illinois ki Chicago|Te Whare Wananga o Nova Southeastern|Te Whare Wananga o California, San Francisco HIV+AIDS Mahuru 1, 2019
NCT04249037 Te Whare Wananga o Colorado, Denver|Gilead Sciences HIV+AIDS Maehe 1, 2020

Kaore e tika ana

NCT04132674 Te Whare Mate Infectious Diseases Vancouver Human Immunodeficiency Virus I Infection|Whakamahi Taakaro Noema 26, 2018

Wāhanga 4

NCT04054089 Cristina Mussini|Te Whare Wananga o Modena me Reggio Emilia Nga mate HIV Mahuru 2019

Wāhanga 4

NCT04155554 Azienda Ospedaliera Universitaria Senese|Te Whare Wananga Katorika o te Ngakau Tapu|Ospedale Policlinico San Martino|Azienda Ospedaliera San Paolo|Ospedale Amedeo di Savoia HIV-1-mate Hanuere 29, 2020

Wāhanga 3

NCT02275065 Pūtaiao Gileada Te mate HIV-1 Whiringa-ā-nuku 2014

Wāhanga 1

NCT03711253 Te Whare Wananga o Southern California Te mate HIV whakapeka Oketopa 14, 2019

Wāhanga 4

NCT02400307 Pūtaiao Gileada HIV Paenga-whāwhā 17, 2015

Wāhanga 1

NCT03499483 Hauora Hapori Fenway Te aukati HIV Hanuere 24, 2019

Wāhanga 4

NCT03502005 Midland Research Group, Inc.|Gilead Sciences Te Waarere Whakamatea Tangata Maehe 1, 2018

Wāhanga 4

Hanganga matū

Bictegravir-1611493-60-7

Tiwhikete

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

TE WHAKAMAHI KOI

Quality management1

Tono18Ko nga kaupapa Aromātai Tauritenga Kounga kua whakaaetia4, a6kei te whakamanahia nga kaupapa.

Quality management2

Ko te punaha whakahaere kounga teitei o te ao kua whakatakoto he turanga pakari mo nga hoko.

Quality management3

Ko te tirotiro i te kounga ka haere i roto i te huringa ora katoa o te hua ki te whakarite i te kounga me te hua rongoa.

Quality management4

Ko te roopu Whakahaere Whakahaere Ngaio e tautoko ana i nga hiahia kounga i te wa o te tono me te rehitatanga.

WHAKAMAHI WHAKATANGA

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Itari CAM Board Packaging Raina

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Miihini Whakakii Fette Tiamana

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Hapanihi Viswill Tablet Detector

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Rūma Whakahaere DCS

HOANI

Te mahi tahi o te ao
International cooperation
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Domestic cooperation

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