Doxycycline Hyclate
Papamuri
Ko te Doxycycline hyclate he paturopi [1].
Ko te Doxycycline hyclate he huanga mai i te tetracycline, kei a ia nga mahi o te mate-aahua me te antimicrobial.Ka aukati te Doxycycline i te tukuruatanga huaketo dengue i roto i te vitro me te tikanga e whakawhirinaki ana ki te pāmahana.Ko te uara IC50 ko 52.3μM i te 37°C me te 26.7μM i te 40°C.Ka aukati i te huaketo dengue ma te aukati i te NS2B-NS3 serine protease o te huaketo.Ko te 60μM doxycycline e whakaiti ana i te CPE o nga pūtau kua pangia e DNEV2 [1].
Ko te Doxycycline ka kitea he aukati MMP.Ko te maimoatanga Doxycycline ka whakaiti i nga taumata MMP-8 me -9 me te aukati i te whakaputanga o te kiko MMP-2 me MMP-9.I tua atu, ko te maimoatanga me te doxycycline ka tino whakaitihia te mate o te aneurysms intracranial.Ko te Doxycycline ano te korero he maatete whakamomori i runga i tana aukati i nga matrix metalloproteinases.I tua atu, he kaha te mahi antimalarial a doxycycline me te uara IC50 o 320nM i te 96h in vitro [2, 3].
Tohutoro:
[1] Rothan HA, Mohamed Z, Paydar M, Rahman NA, Yusof R. Te aukati o te doxycycline ki te tukuruatanga huaketo dengue i roto i te vitro.Arch Virol.2014 Apr;159(4):711-8.
[2] Maradni A, Khoshnevisan A, Mousavi SH, Emamirazavi SH, Noruzijavidan A. Te mahi a te matrix metalloproteinases (MMPs) me te MMP inhibitors i runga i te intracranial aneurysms: he tuhinga arotake.Med J Ihirama Repub Iran.2013 Whiringa-ā-rangi;27(4):249-254.
[3] Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML.In vitro me in vivo te kaha antimalarial o nga tetracycline kua arotau.Antimicrob Agents Chemother.2013 Hurae;57(7):3131-6.
Whakaahuatanga
Ko te Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), he paturopi, he kaikawe a-waha me te whanui-whanui metalloproteinase (MMP) aukati [1].
Whakamatautau Haumanu
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| NCT00511875 | Thomas Gardner|Te Putanga Rangahau mo te Huka Huka Tamariki|Milton S. Hershey Medical Center | Retinopathy mate huka | Hōngongoi 2008 | Wāhanga 2 |
| NCT04108897 | Te Whare Wananga o Johns Hopkins | Rosacea | Hepetema 17, 2019 | Wāhanga Moata 1 |
| NCT00631501 | Te Whare Wananga o Kaunas|University Hospital, Linkoeping | Epicondylalgia Lateral (Tuku Tennis) | Kaore e tika ana | |
| NCT02203682 | Te Whare Wananga o Sun Yat-sen | Graves Ophthalmopathy|Mai urupa|Mai kanohi|Mai Tiroi|Mai Punaha Endocrine|Mai Karu, Tukutuku|Hyperthyroidism|Mai Autoimmune|Mai Mate Mate | Hōngongoi 2014 | Wāhanga 2 |
| NCT02005653 | Kaunihera Inia mo te Rangahau Hauora | Filarial;Te mate | Hui-tanguru 2009 | Wāhanga 4 |
| NCT03585140 | Centro Dermatológico Dr. Ladislao de la Pascua | Acne Vulgaris|Whakarerekē Kai | Hanuere 1, 2016 | Kaore e tika ana |
| NCT02147262 | Whare Wananga Hauora o Ljubljana|Te Whare Wananga o Ljubljana Kura Rongoa, Slovenia|Te Whare Wananga Hauora o Vienna|Te Whare Wananga o Harvard | Atrophic Acrodermatitis mau tonu | Hōngongoi 2013 | Kaore e tika ana |
| NCT02220751 | Te Whare Wananga o Sao Paulo|Fundação de Amparo à Pesquisa do Estado de São Paulo | Periodontitis|Momo 2 Diabetes Mellitus | Poutū-te-rangi 2009 | Wāhanga 3 |
| NCT01825408 | Te Whare Wananga o North Carolina, Chapel Hill | Sinusitis | Hui-tanguru 2013 | Wāhanga 4 |
| NCT02884713 | King Faisal Specialist Hospital & Research Centre | KAUPAPA | Pipiri 2013 | Kaore e tika ana |
| NCT02726646 | Te Whare Wananga o Campinas, Brazil|Pontificia Universidade Catolica de Sao Paulo | Periodontitis mau tonu | Pipiri 2015 | Wāhanga 2 |
| NCT00883818 | Whare Hauora Samsung | Te Tongimi Tongimi | Hanuere 2007 | Wāhanga 4 |
| NCT00829790 | Teva Pharmaceuticals USA | Hauora | Oketopa 2006 | Wāhanga 1 |
| NCT01949233 | Te Whare Wananga o Oxford|Oxford University Hospitals NHS Trust | Marfan Syndrome | Whiringa-ā-nuku 2013 | Wāhanga 2 |
| NCT01518192 | Whare Wananga Hauora Ljubljana|Slovenian Research Agency | Erythema Migrans|Nga tohu mate i muri i te Lyme | Pipiri 2006 | Wāhanga 4 |
| NCT02845024 | Te Whare Wananga o Islamic Azad, Tehran | Ko te mate huka me te mate o te waa | Mahuru 2014 | Kaore e tika ana |
| NCT01879930 | Whare Wānanga Hospital Inselspital, Berne | Te mamae o te Pelvic Syndrome|Te mamae o te Tongimi | Noema 2012 | Wāhanga 4 |
| NCT00041977 | CollaGenex Pharmaceuticals | Te hakihaki Rosacea | Pipiri 2002 | Wāhanga 3 |
| NCT02341209 | Rochester General Hospital | Te Putau-T Lymphoma|Mycosis Fungoides|Sezary Syndrome | Hui-tanguru 6, 2018 | Wāhanga 2 |
| NCT00002872 | R | Te mate pukupuku metastatic | Noema 1996 | Wāhanga 3 |
| NCT03162497 | Te Whare Wananga Hauora o Vienna | Nga mate Karu maroke|Meibomian Gland Dysfunction | Hanuere 8, 2018 | Wāhanga 4 |
| NCT01418742 | Gesellschaft fur Medizinische Innovation ?Hamatologie und Onkologie mbH|ClinAssess GmbH | Te mate mate pukupuku | Akuhata 2011 | Wāhanga 2 |
| NCT00980148 | National Institute of Allergy and Infectious Diseases (NIAID) | Te mate Chlamydial | Hakihea 2009 | Wāhanga 3 |
| NCT03342456 | Ko te Tuatoru o Xiangya Hospital o Central South University|Livzon Pharmaceutical Group Inc.|Yung Shin Pharm.Ind. Co., Ltd. | Duodenal Ulcer Na te Helicobacter Pylori | Hakihea 13, 2017 | Wāhanga 4 |
| NCT04310930 | Te Whare Wananga o Queensland|Te Tari Hauora a te Kawanatanga o Ahitereiria|Te Whare Hauora a nga tamariki|Cystic Fibrosis Foundation|Te Whare Wananga o Niucastle|Te Whare Wananga o Griffith|Te Whare Wananga o Erasmus|Te Whare Wananga o Monash|Te Whare Wananga o Copenhagen|Hôpital Cochin|Te Whare Wananga o Ahitereiria Hauora me te Whare Rangahau Hauora|Te Whare Wananga o Melbourne|Te Whare Wananga o James Cook, Queensland, Ahitereiria|Murdoch Childrens Research Institute | Mate Pukakahu Na te Mycobacteria | Maehe 2020 | Wāhanga 2|Wāhanga 3 |
| NCT03709459 | Te Whare Wananga o Kirby|Te Whare Rangahau Hauora me te Hauora o Ahitereiria ki te Tonga|Te Whare Wananga o Monash | Aukati i nga STI | Hakihea 17, 2019 |
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| NCT04067011 | Putanga BioSolutions|Biomedical Advanced Research and Development Authority | Anthrax | Akuhata 12, 2019 | Wāhanga 2 |
| NCT02844634 | British Columbia Center mo te Mana Mate | HIV|Syphilis | Haratua 15, 2018 | Wāhanga 4 |
| NCT00647959 | Mylan Pharmaceuticals | Hauora | Poutū-te-rangi 2006 | Wāhanga 1 |
| NCT00170222 | Whare Hauora Alkmaar | Nga mate Puka Obstructive pulmonary | Hōngongoi 2002 | Wāhanga 4 |
| NCT03075891 | Galderma | Rosacea | Hōngongoi 5, 2017 | Wāhanga 4 |
| NCT00031499 | National Institute of Allergy and Infectious Diseases (NIAID) | Ko te mate huka | Pipiri 2000 | Wāhanga 3 |
| NCT01205464 | Te Whare Wananga o Linkoeping | Te rohirohi|Te mamae o te irirangi|Radicular Dysfunction|Cognitive Dysfunction|Paresthesia|Paresis | Hui-tanguru 2005 | Kaore e tika ana |
| NCT01301586 | Nexgen Dermatologics, Inc. | ACNE VULGARIS | Noema 2010 | Wāhanga 1|Wāhanga 2 |
| NCT02305940 | Kareti Imperial London | Te Ma'i Puka Puka Maumau (COPD) | Hōngongoi 2014 | Wāhanga 3 |
| NCT00351182 | Dong-Min Kim|Chosun University Hospital | Horoihia te Typhus | Hepetema 2005 | Wāhanga 3 |
| NCT03334682 | Nantes University Hospital | Te hakihaki | Hanuere 31, 2018 | Wāhanga 3 |
| NCT01788215 | Te Whare Wananga o Rochester | Polycystic Ovarian Syndrome (PCOS)|Kore-te-te-a-te-a-te-Taenga|Nga Androgen | Noema 2010 | Wāhanga 3 |
| NCT03076281 | Sidney Kimmel Cancer Centre at Thomas Jefferson University|Thomas Jefferson University | Larynx|LIP|Kowaha-waha|Pharynx | Paenga-whāwhā 3, 2017 | Wāhanga 2 |
| NCT00439166 | Hamilton Health Sciences Corporation|The Physicians' Services Incorporated Foundation|Te Whare Wananga o McMaster | Te mate a Alzheimer | Hui-tanguru 2007 | Wāhanga 3 |
| NCT02463942 | Whare Hauora Whare Wananga Ljubljana|Te Whare Wananga o Ljubljana Kura Rongoa, Slovenia | Te Encephalitis na te Tick-borne | Mahuru 2014 | Kaore e tika ana |
| NCT00803842 | Te Whare Wananga o Te Taitokerau | Kore Iti Pūtau Pukahukahu Matepukupuku | Oketopa 2008 | Kaore e tika ana |
| NCT02086591 | Te Whare Wananga o Rochester | Te Pakeke Te Tirohanga Nui-Tuku-B Lymphoma|Te Kokukukui Te Putau Kokoku Recurrent|Lymphoma, Follicular|Tawhēwhe B-Cell Lymphoma|Rimoni Malignant - Lymphoplasmacytic|Waldenstrom Macroglobulinemia|Limphoma Lymphocytic Iti|Chronic Lymphocytic Lymphoma-CLLocytic Leukemia (CLL) | Poutū-te-rangi 2014 | Wāhanga 2 |
| NCT03980223 | Te Whare Wananga o California, San Francisco|Te Whare Wananga o Washington|National Institute of Allergy and Infectious Diseases (NIAID)|Mayne Pharma International Pty Ltd|San Francisco Department of Health Public | Gonorrhea|Chlamydia|Syphilis | Noema 26, 2019 | Wāhanga 4 |
| NCT00355459 | Te Whare Wananga o Texas Southwestern Medical Center | Ko te mate kanohi maroke | Akuhata 2005 | Kaore e tika ana |
| NCT01254799 | Omar Mamdouh Shaaban|Te Whare Wananga o Assiut | Te whakaheke toto | Hanuere 2008 | Wāhanga 3 |
| NCT01547325 | NanoSHIFT LLC|Te Tari Tiaki o Amerika | Nga Taonga Haparapara kua whakakorehia | Haratua 2012 | Kaore e tika ana |
| NCT00653380 | Par Pharmaceutical, Inc.|Anapharm | Hei Whakatau i te Bioequivalence i raro i nga tikanga nohopuku | Hepetema 1999 | Wāhanga 1 |
| NCT00635609 | Warner Chilcott | Te hakihaki | Poutū-te-rangi 2008 | Wāhanga 4 |
| NCT03765931 | Institut de Recherche pour le Developpement | kirikaa | Hōngongoi 2016 | Wāhanga 4 |
| NCT01160640 | Harold Wiesenfeld|National Institute of Allergy and Infectious Diseases (NIAID)|Te Whare Wananga o Pittsburgh | Te mate mumura o te pelvic | Noema 2010 | Wāhanga 2 |
| NCT01756833 | Te Whare Wananga o Maryland, Baltimore|National Institute on Aging (NIA) | Aneuri | Haratua 2013 | Wāhanga 2 |
| NCT00688064 | Galderma | Haehae Nui | Akuhata 2008 | Wāhanga 3 |
| NCT01320033 | Galderma | Te hakihaki | Maehe 29, 2011 | Wāhanga 2 |
| NCT03397004 | Michael's Hospital, Toronto|Barrow Neurological Institute|Duke University|Feinstein Institute for Medical Research|Te Whare Wananga o Pittsburgh|Sunnybrook Health Sciences Centre | Telangiectasia whakaheke toto (HHT) | Mahuru 12, 2018 | Wāhanga 2 |
| NCT01635530 | Te Whare Wananga o Turku | Lyme Neuroborreliosis | Akuhata 2012 | Wāhanga 4 |
| NCT03727620 | Te Whare Wananga o Mohammed V Souissi | Periodontitis Kariri | Hanuere 6, 2014 | Wāhanga 1|Wāhanga 2 |
| NCT02688738 | Rothman Institute Orthopedics | Propionibacterium | Poutū-te-rangi 2015 | Kaore e tika ana |
| NCT00358462 | Te Whare Wananga o Washington|National Institute of Allergy and Infectious Diseases (NIAID) | Uretritis | Hanuere 2007 | Wāhanga 3 |
| NCT02864550 | British Columbia Center mo te Mana Mate | Syphilis|Nga mate tuku i te wahine | Akuhata 15, 2019 | Wāhanga 4 |
| NCT01595594 | Te Whare Wananga o Sao Paulo|Fundação de Amparo à Pesquisa do Estado de São Paulo | Te mate o te waa|te mate huka Momo 2 | Poutū-te-rangi 2010 | Wāhanga 3 |
| NCT00964834 | PharmAthene, Inc.|National Institute of Health (NIH)|Medarex|Quintiles, Inc.|Tari Hauora me nga Ratonga Tangata | Anthrax | Hōngongoi 2009 | Wāhanga 1 |
| NCT01809444 | Te Whare Wananga o Sun Yat-sen | Nga mate othalmopathies e hono ana ki te thyroid | Noema 2012 | Wāhanga 2|Wāhanga 3 |
| NCT01590082 | MD Anderson Cancer Centre|National Institute of Health (NIH)|National Cancer Institute (NCI) | Melanoma | Noema 2012 | Wāhanga 1|Wāhanga 2 |
| NCT00207584 | Pokapū Mana me te Aukati i te mate | Mycoplasma Pneumoniae | Hanuere 1994 | Kaore e tika ana |
| NCT00775177 | Ranbaxy Laboratories Limited|Ranbaxy Inc. | Hauora | Pipiri 2005 | Kaore e tika ana |
| NCT03462329 | Whare Wananga Hauora Ljubljana | Erythema Migrans | Pipiri 1, 2018 | Kaore e tika ana |
| NCT00000403 | Te Whare Wananga o Indiana|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|National Institute on Aging (NIA) | Osteoarthritis | Hepetema 1996 | Wāhanga 3 |
| NCT03508232 | Te Whare Wananga o Alberta|Royal Alexandra Hospital | Te Wāhanga ST Te Whakanuia Myocardial Infarction|Ngakau Ngakau | Hanuere 6, 2020 | Wāhanga 2 |
| NCT02553473 | Sorlandet Hospital HF | Neuroborreliosis, Borrelia Burgdorferi | Whiringa-ā-nuku 2015 | Wāhanga 3 |
| NCT02207556 | Kareti Hauora o Wisconsin | Amyloidosis Pūnaha Tuatahi | Oketopa 1, 2014 | Wāhanga 2 |
| NCT01783106 | Royal Liverpool University Hospital|National Association for Colitis and Crohn's Disease|National Institute for Health Research, United Kingdom | Te mate a Crohn | Hui-tanguru 1, 2014 | Wāhanga 2 |
| NCT00353743 | Hospital de Clinicas de Porto Alegre | Te materoto, Septic | Haratua 2006 | Kaore e tika ana |
| NCT01727973 | Te Whare Wananga o Sun Yat-sen | Graves Ophthalmopathy|Mai urupa|Mai kanohi|Mai Tiroi|Mai Punaha Endocrine|Mai Karu, Tukutuku|Hyperthyroidism|Mai Autoimmune|Mai Mate Mate | Whiringa-ā-nuku 2012 | Wāhanga 1|Wāhanga 2 |
| NCT00857038 | Medical Center Alkmaar|Leiden University Medical Center|Te Whare Wananga o Amsterdam | Te mate Puka Puka Puka Maumau|Mua|Pulmonary Emphysema | Paenga-whāwhā 2009 | Wāhanga 4 |
| NCT02774993 | National University Hospital, Singapore|Tan Tock Seng Hospital|National University, Singapore|A*Star | Te mate kohi | Mahuru 2015 | Wāhanga 2 |
| NCT03474458 | IRCCS Policlinico S. Matteo | Ko te ngakau AL Amyloidosis | Hui-tanguru 11, 2019 | Wāhanga 2|Wāhanga 3 |
| NCT02874430 | Sidney Kimmel Cancer Centre at Thomas Jefferson University|Thomas Jefferson University | Te mate pukupuku uma|Endometrial Clear Cell Adenocarcinoma|Endometrial Serous Adenocarcinoma|Uterine Corpus Cancer|Uterine Corpus Carcinosarcoma | Pipiri 8, 2016 | Wāhanga 2 |
| NCT00016835 | Te Whare Wananga o Michigan|National Institute of Dental and Craniofacial Research (NIDCR) | Te mate o te wa-roopu|Te mate huka Mellitus, Momo 2 | Oketopa 17, 2001 | Wāhanga 2 |
| NCT00064766 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Te Toto Endometrial|Mai Waarua | Hui-tanguru 2003 | Wāhanga 4 |
| NCT00803452 | Te Whare Wananga o Louisville | Blepharitis | Hōngongoi 2008 | Wāhanga 4 |
| NCT01434173 | Bayer|RTI Health Solutions | Te Taonga Ate Na te Taakaro | Hōngongoi 2001 |
|
| NCT00126204 | Barnes-Jewish Hospital | Aortic Aneurysm | Poutū-te-rangi 2004 | Kaore e tika ana |
| NCT01917721 | Hawaii Pacific Health | Te mate Kawasaki|Coronary Aneurysm | Whiringa-ā-nuku 2013 | Wāhanga 2 |
| NCT02775695 | Kareti Hauora o Wisconsin | Te mate pukupuku Pancreatic Resectable | Paenga-whāwhā 3, 2017 | Wāhanga 2 |
| NCT03824340 | Aljazeera Hospital | Te kore tamariki | Hanuere 30, 2019 | Kaore e tika ana |
| NCT01847976 | Ottawa Hospital Research Institute|Canadian Breast Cancer Foundation | Te mamae | Akuhata 2013 | Wāhanga 2 |
| NCT02850913 | Te Whare Wananga o Makerere|Te Whare Wananga o Oxford | Nga hopukanga | Mahuru 5, 2016 | Wāhanga 2 |
| NCT00764361 | NanoSHIFT LLC | Mate Huka Waewae mate huka | Hanuere 2009 | Wāhanga 2 |
| NCT02036528 | Royer Biomedical, Inc. | Nga Waewae Mate Huka Huka | Hanuere 2014 | Wāhanga 1|Wāhanga 2 |
| NCT01661985 | Ostergotland County Council, Sweden|Statens Serum Institut | Urethritis|Cervicitis|Iraraa Mycoplasma Infection|Chlamydia Trachomatis | Hui-tanguru 2010 | Wāhanga 4 |
| NCT01380483 | Par Pharmaceutical, Inc.|Anapharm | Hei Whakatau i te Bioequivalence i raro i nga tikanga nohopuku | Hanuere 2000 | Wāhanga 1 |
| NCT00648180 | Mylan Pharmaceuticals | Hauora | Hōngongoi 2005 | Wāhanga 1 |
| NCT01426269 | Galderma Laboratories, LP | Rosacea | Mahuru 2011 | Wāhanga 4 |
| NCT02753426 | Te Whare Wananga o California, San Francisco | Te mate Takihi mau tonu|Maiora ngakau | Paenga-whāwhā 2016 | Wāhanga 1 |
| NCT02583282 | Paerua Institute of Medical Education and Research | Te Hunga-a-Pure-a-Toi | Akuhata 1, 2015 | Kaore e tika ana |
| NCT02927496 | Te Ope Mahi mo te Hauora o te Ao|Te Pokapi mo te Whanaketanga Ao o Amerika (USAID) | Lymphedema|Lymphatic Filariasis|Filariasis | Pipiri 19, 2018 | Wāhanga 3 |
| NCT00652795 | Par Pharmaceutical, Inc.|Anapharm | Hei Whakatau i te Bioequivalence i raro i nga tikanga nohopuku | Hōngongoi 2004 | Wāhanga 1 |
| NCT03956212 | Whare Hauora Whare Wananga Ljubljana|Te Whare Wananga o Ljubljana Kura Rongoa, Slovenia | Erythema Migrans | Pipiri 1, 2017 | Kaore e tika ana |
| NCT00855595 | Bayer | Papulopustular Rosacea | Hui-tanguru 2009 | Wāhanga 4 |
| NCT03457636 | Derm Research, PLLC | hakihaki | Maehe 19, 2018 | Wāhanga 4 |
| NCT02894268 | Sir Run Run Shaw Hospital | Te mate Helicobacter Pylori | Hui-tanguru 2016 | Wāhanga 4 |
| NCT03465774 | MD Anderson Cancer Centre|National Cancer Institute (NCI) | Te Hunga-a-Pure-a-Toi | Maehe 8, 2018 | Wāhanga Moata 1 |
Hanganga matū
Tono18Ko nga kaupapa Aromātai Tauritenga Kounga kua whakaaetia4, a6kei te whakamanahia nga kaupapa.
Ko te punaha whakahaere kounga teitei o te ao kua whakatakoto he turanga pakari mo nga hoko.
Ko te tirotiro i te kounga ka haere i roto i te huringa ora katoa o te hua ki te whakarite i te kounga me te hua rongoa.
Ko te roopu Whakahaere Whakahaere Ngaio e tautoko ana i nga hiahia kounga i te wa o te tono me te rehitatanga.
Korea Countec Pounamu Whakapai Raina
Taiwan CVC Pounamu Packaging Raina
Itari CAM Board Packaging Raina
Miihini Whakakii Fette Tiamana
Hapanihi Viswill Tablet Detector
Rūma Whakahaere DCS
Te mahi tahi o te ao
Te mahi tahi a-whare
Tuhia to korero ki konei ka tukuna mai ki a matou
