Papamuri

Ko te Canagliflozin he mea hou, he kaha, he tino kowhiria te konutai konutai glucose co-transporter (SGLT) 2 aukati [1].Kua whakamatauhia ka taea e Canagliflozin te whakanui ake i te whakahekenga o te huka mimi ma te whakaheke i te paepae hukahuka renal me te whakaheke i te whakauru ano o te huka toto.

Kua whakaatuhia te Canagliflozin ki te aukati i te Na + -mediated 14C-AMG intakes i CHO-hSGLT2, CHO-rat SGLT2 me CHO-kiore SGLT2 me nga uara IC50 o 4.4, 3.7 me 2.0 nM, ia [1].

Ko te Canagliflozin te korero mo te whakaheke i nga taumata huka toto (BG) i runga i te horopeta i roto i nga kiore db/db me te ngako mate huka Zucker (ZDF) kiore.I tua atu, kua whakamatauhia e te canagliflozin te whakaheke i te tauwehenga whakawhiti manawa, me te taumaha tinana i roto i nga kiore DIO me nga kiore ZDF [1].

Ka taea te tango i te Canagliflozin ma te waha.

Tohutoro:
[1] Liang Y1, Arakawa K, Ueta K, Matsushita Y, Kuriyama C Martin T, Du F, Liu Y, Xu J, Conway B, Conway J, Polidori D, Ways K, Demarest K. Te paanga o te canagliflozin ki te paepae renal mo te huka, te glycemia, me te taumaha tinana i roto i nga tauira kararehe noa me te mate huka.PLoS Kotahi.2012;7(2):e30555
[2] Sarnoski-Brocavich S, Hilas O. Canagliflozin (Invokana), he Agent Oral Novel mo te mate huka Momo-2.P T. 2013 Noema;38(11):656-66

Tohunga Hua

Bahia Abbas Moussa, Marianne Alphonse Mahrouse, et al."Nga tikanga whakatau rereke mo te whakahaere i te hihinga īnaki: Te tono mo te whakatau i nga raau taero hypoglycemic hou i hangaia i roto i o raatau momo inenga rongoa."Spectrochimica Acta Wāhanga A: Molecular and Biomolecular Spectroscopy Kei runga ipurangi 20 Pipiri 2018.

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