Daclatasvir Dihydrochloride
Whakaahuatanga
Ko te Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) he kaha, he kaha ki te waha.HCV NS5A pūmuaaukati kiEC50s awhe o 9-146 pm mote maha o nga momo momo tauira HCV.Ko te Daclatasvir dihydrochloride ano heanion waro kawe polypeptide 1B (OATP1B)aOATP1B3aukati kiIC50s o 1.5 µM me 3.27 µM, ia.
IC50& Whainga
EC50: 50 pM (HCV tauira tauira ira momo 1a), 9 pM (HCV tauira tauira ira momo 1b), 71 pM (HCV tauira tauira ira momo 2a), 146 pM (HCV tauira tauira ira momo 3a), 12 pM (HCV tauira tauira ira momo 4a) me HCV tauira ira momoira 5a)[1]
Kd: 8 nM (NS5A33-202) me 210 nM (NS5A26-202)[2]
IC50: 1.5 µM (OATP1B) me 3.27 µM (OATP1B3)[3]
In Vitro
Ko Daclatasvir (BMS-790052) e whakaatu ana i te mahi aukati kaha ki nga momo momo ira katoa i whakamatauria, me te EC50nga uara mai i te 9 pm ki te 146 pm.Ka aukati a Daclatasvir i te HCV tauira ira momo 1a, 1b, 2a, 3a, 4a me 5a me te EC50uara o 50 pm, 9 pm, 71 pm, 146 pm, 12 pm me 33 pm, ia.Ko Daclatasvir he aukati kaha o te JFH-1 genotype 2a huaketo hopuhopu e tukurua ana i roto i te ahurea pūtau (EC50=28pm)[1].Ka herea e Daclatasvir (BMS-790052) ki NS5A33-202 me NS5A26-202 me Kds o 8 nM me 210 nM, ia[2].
Rokiroki
| Paura | -20°C | 3 tau |
| 4°C | 2 tau | |
| I te whakarewa | -80°C | 6 marama |
| -20°C | 1 marama |
Whakamatautau Haumanu
| Nama NCT | Kaitautoko | Tikanga | Rā Tīmata | Wāhanga |
| NCT03369327 | Te Whare Wananga o Te Whare Wananga o Tehran|RojanPharma Pharmaceutical Company | Te Mate Hepatitis C, Te Whakautu ki te Hauora o|Human Immunodeficiency Virus | Hanuere 1, 2017 | Wāhanga 3 |
| NCT03485846 | R-Pharm|Almedis | Hepatitis C moroiti 1b | Noema 27, 2017 | Wāhanga 2 |
| NCT01016912 | Bristol-Myers Squibb | Te Mate Hepatitis C | Hakihea 2009 | Wāhanga 2 |
| NCT01629732 | Bristol-Myers Squibb | Hepatitis C Virus | Poutū-te-rangi 2013 | Wāhanga 2 |
| NCT01497834 | Bristol-Myers Squibb | Te mate pukupuku C | Hanuere 2012 | Wāhanga 3 |
| NCT01973049 | Bristol-Myers Squibb | Te mate pukupuku C | Hakihea 2013 | Wāhanga 3 |
| NCT00663208 | Bristol-Myers Squibb | Hepatitis C | Haratua 2008 | Wāhanga 2 |
| NCT02576314 | Te Whare Rangahau Tangata me te Hauora|Beijing 302 Hospital | Te mate Hepatitis C mau tonu | Haratua 2015 | Wāhanga 3 |
| NCT02756936 | Te Whare Rangahau Tuturu, Ihipa|Zeta Pharma Pharmaceutical Ahumahi | Hauora | Hui-tanguru 2016 | Wāhanga 1 |
| NCT02771405 | National Hepatology & Tropical Medicine Research Institute|Te Whare Wananga o Cairo | Hepatitis C, Maumau|Hepatocellular Carcinoma | Poutū-te-rangi 2016 | Wāhanga 3 |
| NCT03706898 | Viriom | HIV-1-infection|Hepatic Impairment | Oketopa 1, 2018 | Wāhanga 1 |
| NCT02319031 | Bristol-Myers Squibb | Te mate pukupuku C | Hui-tanguru 2015 | Wāhanga 3 |
| NCT02124044 | National Institutes of Health Clinical Centre (CC)|National Institute of Allergy and Infectious Diseases (NIAID)|Bristol-Myers Squibb | HIV-HCV | Hui-tanguru 2014 | Wāhanga 2 |
| NCT02551861 | Bristol-Myers Squibb | Te mate pukupuku C | Hakihea 2015 | Wāhanga 2 |
| NCT00859053 | Bristol-Myers Squibb | Te Hepatic Insufficiency | Poutū-te-rangi 2009 | Wāhanga 1 |
| NCT01257204 | Bristol-Myers Squibb | Hepatitis C Virus | Hakihea 2010 | Wāhanga 2 |
| NCT03063879 | Te Whare Wananga o Te Whare Wananga o Tehran|Te Whare Wananga o Ahvaz Jundishapur Te Whare Wananga o nga Putaiao Hauora|Te Whare Wananga o Shiraz o Nga Putaiao Hauora|Te Whare Wananga o Hamana | Hepatitis C, Maamaa|Maiuhia te Rahunga Renal | Paenga-whāwhā 1, 2017 | Wāhanga 4 |
| NCT01017575 | Bristol-Myers Squibb | Te Mate Hepatitis C | Hakihea 2009 | Wāhanga 2 |
| NCT02865369 | Sang Gyune Kim|Te Whare Wananga o Seoul Boramae Hospital|Severance Hospital|Inha University Hospital|Korea University|Gachon University Gil Medical Center|Hanyang University Seoul Hospital|Ewha Womans University Mokdong Hospital|Bristol-Myers Squibb|Soonchunhyang University Hospital | Hepatitis C | Mahuru 2016 |
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| NCT04070235 | Nanjing Sanhome Pharmaceutical, Co., Ltd. | Hepatitis C, Maumau | Maehe 29, 2019 | Wāhanga 2|Wāhanga 3 |
| NCT03487848 | Bristol-Myers Squibb | Hepatitis C|Hepatitis Maumau | Haratua 18, 2018 | Wāhanga 2 |
| NCT00904059 | Bristol-Myers Squibb | Te mate pukupuku C | Haratua 2009 | Wāhanga 1 |
| NCT02107365 | French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Bristol-Myers Squibb | Hepatitis C Virus Genotype 4 Infection | Noema 2013 | Wāhanga 2 |
| NCT02397395 | Janssen R&D Ireland | Te Paheketanga Renal|Whakamutunga-waahi Mate Renal | Haratua 2015 | Wāhanga 2 |
| NCT03169348 | Te Whare Wananga o Assiut | Te mate pukupuku C | Noema 1, 2017 | Kaore e tika ana |
| NCT02323594 | Bristol-Myers Squibb | Te Mate Hepatitis C | Hakihea 2014 | Wāhanga 1 |
| NCT03537196 | French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS) | Hepatitis C|Whakamahi Taakaro|Hepatitis C Viral | Noema 13, 2018 | Wāhanga 4 |
| NCT02103569 | Bristol-Myers Squibb | Te mate pukupuku C | Paenga-whāwhā 2014 | Wāhanga 1 |
| NCT02772744 | Te Whare Wananga o Zagazig|Cairo University | Te mate pukupuku C | Noema 1, 2017 |
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| NCT01718158 | Bristol-Myers Squibb | Te mate pukupuku C | Hanuere 2013 | Wāhanga 3 |
| NCT02496078 | Bristol-Myers Squibb | Te mate pukupuku C | Akuhata 2015 | Wāhanga 3 |
| NCT01425970 | Bristol-Myers Squibb | Te mate pukupuku C | Haratua 2012 | Wāhanga 2 |
| NCT01471574 | Bristol-Myers Squibb | Hepatitis C, Tohua 1 | Hakihea 2011 | Wāhanga 3 |
| NCT01573351 | Bristol-Myers Squibb | Hepatitis C Virus | Haratua 2012 | Wāhanga 3 |
| NCT01938625 | Janssen R&D Ireland | Hepatitis C, Maumau | Hakihea 12, 2013 | Wāhanga 2 |
| NCT01492426 | Bristol-Myers Squibb | Te mate pukupuku C | Hanuere 2012 | Wāhanga 3 |
| NCT03480932 | Johns Hopkins Bloomberg School of Health Public|National Institute on Drug Abuse (NIDA)|YR Gaitonde Center for AIDS Research and Education | Hepatitis C, Maumau | Hui-tanguru 2, 2018 | Wāhanga 2|Wāhanga 3 |
| NCT03163849 | Te Whare Wananga o Assiut | Hepatitis ma'i c | Mahuru 1, 2019 | Wāhanga 3 |
| NCT01581203 | Bristol-Myers Squibb | Hepatitis C Virus | Haratua 2012 | Wāhanga 3 |
| NCT01492504 | Bristol-Myers Squibb | Te mate pukupuku C | Hui-tanguru 7, 2012 |
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| NCT03686722 | Mohamed Raslan|Te Whare Wananga o Ain Shams|Te Whare Rangahau Taaka, Kairo, Ihipa | Te mate huka, Momo 2|Hepatitis C|Whakawhitinga Taakaro | Mahuru 9, 2017 | Wāhanga 1 |
| NCT02262728 | Janssen Research & Development, LLC | Hepatitis C, Maumau | Hepetema 30, 2014 | Wāhanga 2 |
| NCT02349048 | Janssen Research & Development, LLC | Hepatitis C Virus | Hanuere 2015 | Wāhanga 2 |
| NCT03882307 | Te Whare Wananga o Assiut | Hepatitis C, Maumau | Haratua 2020 | Wāhanga Moata 1 |
| NCT02758509 | Parc de Salut Mar | Hepatitis C|Cirrhosis | Hanuere 1, 2010 |
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| NCT01795911 | Bristol-Myers Squibb | Te mate pukupuku C | Poutū-te-rangi 2013 | Wāhanga 2 |
| NCT03549832 | Te Whare Wananga o Assiut|Te Whare Wananga o Sohag|Te Whare Wananga o South Valley | HCV Coinfection | Hanuere 1, 2018 | Kaore e tika ana |
| NCT02161939 | Bristol-Myers Squibb | Hepatitis C |
| |
| NCT01309932 | Bristol-Myers Squibb | Te mate pukupuku C | Poutū-te-rangi 2011 | Wāhanga 2 |
| NCT01995266 | Bristol-Myers Squibb | Te mate pukupuku C | Hui-tanguru 28, 2014 | Wāhanga 3 |
| NCT02640157 | AbbVie | Hepatitis C|Hepatitis C Virus|Genotype 3 Hepatitis C Virus | Hakihea 2015 | Wāhanga 3 |
| NCT02032875 | Bristol-Myers Squibb | Te mate pukupuku C | Poutū-te-rangi 2014 | Wāhanga 3 |
| NCT02624063 | Te Whare Wananga Federal o São Paulo | Hepatitis C, Maumau | Hakihea 2015 | Wāhanga 4 |
| NCT00546715 | Bristol-Myers Squibb | Hepatitis C | Noema 2007 | Wāhanga 1|Wāhanga 2 |
| NCT01718145 | Bristol-Myers Squibb | Hepatitis C Virus Infection | Noema 2012 | Wāhanga 3 |
| NCT01616524 | Bristol-Myers Squibb | Hepatitis C Virus (HCV) | Hōngongoi 2012 | Wāhanga 3 |
| NCT02032901 | Bristol-Myers Squibb | Te mate pukupuku C | Hanuere 2014 | Wāhanga 3 |
| NCT03540212 | Te Whare Wananga o Ain Shams | Te mate HCV mau tonu | Hakihea 10, 2017 | Wāhanga 2|Wāhanga 3 |
| NCT02097966 | Bristol-Myers Squibb | Hepatitis C |
| |
| NCT02596880 | Te Whare Wananga o Te Whare Wananga Hauora | Hepatitis C|Cirrhosis | Mahuru 2015 | Wāhanga 3 |
| NCT04019717 | Atea Pharmaceuticals, Inc. | Hepatitis C|Hepatitis C, Maamaa|Maamaa Hepatitis C|Hepatitis C Virus Infection|HCV Infection | Pipiri 20, 2019 | Wāhanga 2 |
| NCT02992457 | Te Whare Wananga o Tanta | Te mate pukupuku C | Hanuere 2015 | Wāhanga 4 |
| NCT03547895 | Te Whare Wananga o Zagazig | Cirrhosis whakaheke | Pipiri 1, 2015 | Kaore e tika ana |
| NCT03004625 | Kaohsiung Medical University Chung-Ho Memorial Hospital|Chang Gung Memorial Hospital|National Taiwan University Hospital|Taipei Veterans General Hospital, Taiwan|China Medical University Hospital|National Cheng-Kung University Hospital | Te mate pukupuku C | Noema 2016 | Wāhanga 3 |
| NCT01051414 | Bristol-Myers Squibb | Te Mate Hepatitis C | Paenga-whāwhā 2010 | Wāhanga 2 |
| NCT02309450 | French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Bristol-Myers Squibb | Hepatitis C Virus Genotype 4 Infection | Hakihea 2014 | Wāhanga 2 |
| NCT01628692 | Bristol-Myers Squibb|Janssen Research & Development, LLC | Hepatitis C Virus | Hōngongoi 2012 | Wāhanga 2 |
| NCT03186313 | Te hohipera ate o Ihipa|Wadi El Nil Hospital | Te mate pukupuku C | Mahuru 2016 | Wāhanga 3 |
| NCT03063723 | Tuatoru Hononga Hospital, Sun Yat-Sen University | Hepatitis C mau tonu (Mauiui) | Hanuere 1, 2016 |
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| NCT00983957 | Bristol-Myers Squibb | Hepatitis C | Oketopa 2009 | Wāhanga 1 |
| NCT01725542 | French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Bristol-Myers Squibb | Ko te HCV-HIV-Hiki-tahi | Hakihea 2012 | Wāhanga 2 |
| NCT02282709 | Te Tuāpapa mo te Rangahau ate | Hepatitis C | Hui-tanguru 2014 | Wāhanga 3 |
| NCT02032888 | Bristol-Myers Squibb | Te mate pukupuku C | Hui-tanguru 2014 | Wāhanga 3 |
| NCT03247296 | Te Whare Wananga o MTI | Te mate pukupuku C | Hui-tanguru 28, 2017 |
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| NCT01389323 | Bristol-Myers Squibb | Te mate pukupuku C | Mahuru 2011 | Wāhanga 3 |
| NCT02556086 | Bristol-Myers Squibb | Te mate pukupuku C | Hakihea 2015 | Wāhanga 2 |
| NCT01741545 | Bristol-Myers Squibb | Hepatitis C Virus | Maehe 31, 2013 | Wāhanga 3 |
| NCT01866930 | Bristol-Myers Squibb | Te mate Hepatitis C mau tonu | Hōngongoi 11, 2013 | Wāhanga 3 |
| NCT02268864 | Janssen-Cilag International NV | Hepatitis C, Maumau | Hanuere 2015 | Wāhanga 2 |
| NCT01797848 | Bristol-Myers Squibb | Te mate pukupuku C | Pipiri 2014 | Wāhanga 3 |
| NCT03166280 | Eman Sayed Hassan Abd Allah|Te Whare Wananga o Assiut | Te mate pukupuku C | Pipiri 2017 |
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| NCT02159352 | Bristol-Myers Squibb | Te mate pukupuku C | Pipiri 2014 | Wāhanga 1 |
| NCT01125189 | Bristol-Myers Squibb | Hepatitis C Virus | Hōngongoi 2010 | Wāhanga 2 |
| NCT03748745 | Nanjing Sanhome Pharmaceutical, Co., Ltd. | Whakawhanaunga Tarukino | Noema 19, 2018 | Wāhanga 1 |
| NCT01012895 | Bristol-Myers Squibb | Hepatitis C | Hakihea 2009 | Wāhanga 2 |
| NCT02565888 | Te Whare Wananga o Radboud | Hepatitis C|HIV | Noema 2015 | Wāhanga 1 |
| NCT02555943 | Te Whare Rangahau Tangata me te Hauora|Beijing 302 Hospital|Nanfang Hospital of Southern Medical University | Te Mate Mate Karere C|Hepatitis HBV|Hepatitis B Reactivation | Hui-tanguru 2015 | Wāhanga 2|Wāhanga 3 |
| NCT02304159 | Tarek I. Hassanein, MD, FACP, FAG, AGAF|Te Whare Rangahau o California ki te Tonga | Hepatitis C|Cirrhosis | Hanuere 2015 | Wāhanga 4 |
| NCT02580474 | Waiata Myeong Jun|Bristol-Myers Squibb|Te Whare Wananga o Soonchunhyang|Te Whare Wananga o Dankook|Te Whare Wananga o Chungnam National University|Te Whare Wananga o Konyang|Te Whare Wananga o Eulji|Te Whare Wananga o Saint Vincent, Korea|Te Whare Wananga o Konkuk|Te Whare Wananga o Cheongju St. Mary's, Cheongju , Korea|Severance Hospital|Korea University Guro Hospital|Eulji General Hospital|Te Whare Wananga Katorika o Korea | Te mate pukupuku C | Hui-tanguru 2016 | Wāhanga 4 |
| NCT02104843 | Bristol-Myers Squibb | Te mate pukupuku C | Paenga-whāwhā 2014 | Wāhanga 1 |
| NCT01428063 | Bristol-Myers Squibb | Hepatitis C Virus Infection | Mahuru 2011 | Wāhanga 2 |
| NCT02123654 | Bristol-Myers Squibb | Hepatitis C Virus Infection | Paenga-whāwhā 2014 | Wāhanga 3 |
| NCT02565862 | Te Whare Wananga o Radboud | Hepatitis C|Hua Hukaheke Mellitus|Tauturu Taapiri | Hanuere 2016 | Wāhanga 1 |
| NCT04211844 | Te Whare Wananga o Ain Shams | Hepatitis C | Oketopa 1, 2019 |
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| NCT00874770 | Bristol-Myers Squibb | Te Mate Hepatitis C | Pipiri 2009 | Wāhanga 2 |
| NCT03883698 | Sanjay Gandhi Postgraduate Institute of Medical Sciences | Kore Nga Takihi, Maumau|Hepatitis C | Maehe 15, 2019 | Wāhanga 3 |
| NCT01448044 | Bristol-Myers Squibb | Te mate pukupuku C | Hakihea 2011 | Wāhanga 3 |
| NCT01359644 | Bristol-Myers Squibb|Pharmasset | Hepatitis C | Pipiri 2011 | Wāhanga 2 |
| NCT01842451 | Vertex Pharmaceuticals Incorporated | Hepatitis C|CHC|HCV|Hepatitis C | Pipiri 2013 | Wāhanga 2 |
| NCT02762448 | Tainan Municipal Hospital | Te mate pukupuku c | Hōngongoi 2016 |
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| NCT02473211 | Te Whare Rangahau Tangata me te Hauora|Beijing 302 Hospital | Te mate Hepatitis C mau tonu | Hanuere 2015 | Wāhanga 2|Wāhanga 3 |
| NCT01455090 | Bristol-Myers Squibb | Hepatitis C | Noema 30, 2011 | Wāhanga 2 |
| NCT03490097 | Te Whare Wananga o Ain Shams | Te Hepatitis C|Metabolic Syndrome | Hakihea 1, 2017 | Wāhanga 2|Wāhanga 3 |
| NCT01170962 | Bristol-Myers Squibb | Hepatitis C Virus | Akuhata 2010 | Wāhanga 2 |
| NCT02333292 | Te Whare Wananga o Valme|Hospital del SAS de Jerez|Hospital General Universitario Elche|Hospital La Línea de la Concepción|Complexo Hospitalario Universitario de A Coruña|Hospital de Figueres|Hospital Universitario Puerto Real|Hospital Universitario Virgen de la Victoria|Hospital Universitario de Canarias Hospital General Universitario de Alicante|Hospital Universitario Araba|Hospital Royo Vilanova|Hospital Universitario de Burgos|Complejo Hospitalario Universitario de Huelva|Hospital Universitario Reina Sofia de Cordoba|Hospital Universitario Virgen Macarena|Complexo Hospitalario Universitario de Vigo | Navarra|Hospital Clinico Universitario San Cecilio|Hospital Universitario La Fe|Hospital General Universitario de Valencia|Hospital Universitario Infanta Leonor|Hospital Universitario de Gran Canaria|Hospital General Universitario Santa Lucía|Centro Penitenciario Alicante 1|Hospital Virgen Regional Universitario| ra Luz|Hospital General Universitario de Castellón|Hospital Parc Taulí, Sabadell | Te mate Hepatitis C mau tonu | Hakihea 2014 |
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| NCT03200184 | Te Whare Wananga o Te Whare Wananga Hauora | Te mate pukupuku C | Mahuru 1, 2016 | Wāhanga 4 |
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Tono18Ko nga kaupapa Aromātai Tauritenga Kounga kua whakaaetia4, a6kei te whakamanahia nga kaupapa.
Ko te punaha whakahaere kounga teitei o te ao kua whakatakoto he turanga pakari mo nga hoko.
Ko te tirotiro i te kounga ka haere i roto i te huringa ora katoa o te hua ki te whakarite i te kounga me te hua rongoa.
Ko te roopu Whakahaere Whakahaere Ngaio e tautoko ana i nga hiahia kounga i te wa o te tono me te rehitatanga.
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