Venetoclax 1257044-40-8

Whakaahuatanga Poto:

Ingoa API Tohutohu Kaihanga hou Te Ra Whakamutunga Patent(Te US)
Venetoclax 1257044-40-8 CLL Abbvie Hune.27,2031


Taipitopito Hua

Tohu Hua

WHAKAMAHI HUA

维奈妥拉 Venetoclax 1257044-40-8 Roto-whare
VCL-6A 98549-88-3 Roto-whare
VCL-7A 1235865-75-4 Roto-whare
VCLM2 1228780-72-0 Roto-whare
VCLM2-2HCl 1628047-87-9 Roto-whare
VCLM3 1228779-96-1 Roto-whare

GIngoa kaha:venetoclax (ven ET oh klax)
Ingoa Waitohu: Venclexta, Venclexta Tīmata Pack

Ka whakamahia te Venetoclax ki te rongoa i te kanisa lymphocytic mau tonu, te kanisa lymphocytic iti ranei i roto i nga pakeke.Ka whakamahia ko Venetoclax anake, ka whakakotahi ranei me etahi atu rongoa mate pukupuku hei rongoa i enei ahuatanga.

Ka whakamahia te Venetoclax ki te taha o te azacitidine, decitabine, cytarabine ranei hei rongoa i te reukemia myeloid whakapeka.Ko tenei huinga mo te whakamahi i nga pakeke kua 75 tau neke atu ranei, kaore ranei e kaha ki te whakamahi i te chemotherapy paerewa na etahi atu mate hauora.

I etahi wa ka tukuna a Venetoclax i muri i te korenga o etahi atu maimoatanga.

Ka taea ano te whakamahi a Venetoclax mo nga kaupapa kaore i te raarangi i tenei aratohu rongoa.

Whakaahuatanga

Ko te Venetoclax (ABT-199; GDC-0199) he tino kaha, he whiriwhiringa me te waha-a-waha te aukati Bcl-2 me te Ki iti iho i te 0.01 nM.Ko Venetoclax te whakaawe i te autophagy.

In Vitro

Ko Venetoclax (ABT-199) ka kaha te patu i nga pūtau FL5.12-BCL-2 (EC50=4 nM), ka whakaatu a Venetoclax (ABT-199) i nga mahi ngoikore ake ki nga pūtau FL5.12-BCL-XL (EC50=261 nM).Ko te ABT-199 hoki e whakaatu ana i te kowhiringa i roto i nga whakamatautau momo-rua-a-whaa-a-rorohiko, ka whakararu i nga matatini BCL-2-BIM (EC50=3 nM) engari he iti ake te whai hua ki te BCL-XL-BCL-XS (EC50=2.2).μM) ranei MCL-1-NOXA matatini.

I muri i te horopeta a-waha kotahi o te 12.5 mg ia kg te taumaha tinana i roto i nga xenografts i ahu mai i te RS4; 11 nga pūtau (KATOA), ko Venetoclax (ABT-199) ka hua te aukati i te tipu o te puku (TGImax) o te 47% (P<0.001) me te tipu pukupuku. whakaroa (TGD) o 26% (P<0.05)[1].

Ko te maimoatanga o te xenografted (he tauira xenograft kiore o te T-ALL cell line LOUCY) nga pukupuku me te Venetoclax (ABT-199) 100 mg / kg mo nga ra e 4 ka puta he whakahekenga nui o te pikaunga reukemic.

Rokiroki

Paura

-20°C

3 tau

4°C

2 tau
I te whakarewa

-80°C

6 marama

-20°C

1 marama

Hanganga matū

Venetoclax 1257044-40-8

Tiwhikete

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

TE WHAKAMAHI KOI

Quality management1

Tono18Ko nga kaupapa Aromātai Tauritenga Kounga kua whakaaetia4, a6kei te whakamanahia nga kaupapa.

Quality management2

Ko te punaha whakahaere kounga teitei o te ao kua whakatakoto he turanga pakari mo nga hoko.

Quality management3

Ko te tirotiro i te kounga ka haere i roto i te huringa ora katoa o te hua ki te whakarite i te kounga me te hua rongoa.

Quality management4

Ko te roopu Whakahaere Whakahaere Ngaio e tautoko ana i nga hiahia kounga i te wa o te tono me te rehitatanga.

WHAKAMAHI WHAKATANGA

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Miihini Whakakii Fette Tiamana

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Hapanihi Viswill Tablet Detector

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Rūma Whakahaere DCS

HOANI

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