Papamuri

Ko te Tofacitinib citrate, e mohiotia ana ko te CP-690550 citrate, he aukati kaha o te janus kinase 3 (JAK3), he tyrosine kinase hematopoetic cell-restricted tyrosine kinase i roto i te whakawhitinga tohu e whakahaere ana i te oranga o te lymphocyte, te tipu, te rereketanga, me te apoptosis.Ko te aukati he JAK3 motuhake me te whiriwhiringa 1000-nui ake i era atu kinases whanau kore-JAK.I tua atu i te aukati i te JAKS (IC50 = 1 nM), ka aukati ano te tofacitinib citrate i te janus kinase 2 (JAK2) me te janus kinase 1 (JAK1) me te 20- me te 100-fold iti ake te kaha.Heoi, i roto i te rangahau tata nei, ko nga hononga hono (Ki) o te tofacitinib citrate ki a JAK1, JAK2, me JAK3 i kiihia he 1.6 nM, 21.7 nM, me te 6.5 nM.

Tohutoro

Lalitha Vijayakrishnan, R. Venkataramanan me Palak Gulati.Ko te maimoatanga o te mumura me te aukati janus kinase CP-690,550.Trends in Pharmacological Sciences 2011: 32 (1);25-34

Tohunga Hua

• 1. Panagi I, Jennings E, et al."Ka Hurihia e Salmonella Effector SteE te Mammalian Serine/Threonine Kinase GSK3 ki te Tyrosine Kinase hei Arataki i te Polarization Macrophage."Microbe Kaihautū Pūtau.2020;27(1):41–53.e6.PMID:31862381
• 2. McInnes IB, Byers NL, et al."Ko te whakataurite o te baricitinib, upadacitinib, me te tofacitinib i takawaenga i te ture o te tohu cytokine i roto i nga taangata leukocyte tangata."Arthritis Res Ther.2019 Akuhata 2;21(1):183.PMID:31375130
• 3. Liu S, Verma M, et al."Atete pūtaiaki o te ararere momo 2 pūtau lymphoid tūturu i tūroro ki te huangō kino: Te mahi o te thymic stromal lymphopoietin."J Allergy Clin Immunol.2018 Hanuere;141(1):257-268.e6.PMID:28433687
• 4. Zheng, Lufeng, et al."Ko te 3' UTR o te pseudogene CYP4Z2P e whakatairanga ana i te angiogenesis pukupuku i roto i te mate pukupuku o te uma ma te mahi hei ceRNA mo CYP4Z1."Te rangahau me te maimoatanga mate pukupuku o te uma (2015): 1-14.PMID:25701119

Whakaahuatanga

Ko te Tofacitinib citrate he kaitautoko JAK1 / 2/3 e waatea ana me nga IC50 o 1, 20, me te 112 nM, ia.Ko te Tofacitinib citrate he mahi antibacterial, antifungal me te antiviral.

Rokiroki

4°C, tiaki i te marama

*I roto i te whakarewa: -80°C, 6 marama;-20°C, 1 marama (tiaki i te marama)

Hanganga matū

Raraunga Koiora e Pa ana

Raraunga Koiora e Pa ana

Raraunga Koiora e Pa ana

Raraunga Koiora e Pa ana

Raraunga Koiora e Pa ana