Papamuri

Ko te Tofacitinib citrate, e mohiotia ana ko te CP-690550 citrate, he aukati kaha o te janus kinase 3 (JAK3), he tyrosine kinase hematopoetic e herea ana i roto i nga tohu tohu e whakahaere ana i te oranga o te lymphocyte, te whakanui, te rereketanga, me te apoptosis. Ko te aukati he JAK3 motuhake me te kowhiringa 1000-nui ake i era atu kinases whanau kore-JAK. I tua atu i te aukati i te JAKS (IC50 = 1 nM), ka aukati ano te tofacitinib citrate i te janus kinase 2 (JAK2) me te janus kinase 1 (JAK1) me te 20- me te 100-fold iti ake te kaha. Heoi, i roto i te rangahau tata nei, ko nga hononga hono (Ki) o te tofacitinib citrate ki a JAK1, JAK2, me JAK3 i kiihia he 1.6 nM, 21.7 nM, me te 6.5 nM.

Tohutoro

Lalitha Vijayakrishnan, R. Venkataramanan me Palak Gulati. Ko te maimoatanga o te mumura me te aukati janus kinase CP-690,550. Trends in Pharmacological Sciences 2011: 32 (1); 25-34

Tohunga Hua

• 1. Panagi I, Jennings E, et al. "Ka Hurihia e Salmonella Effector SteE te Mammalian Serine/Threonine Kinase GSK3 ki te Tyrosine Kinase hei Arataki i te Polarization Macrophage." Microbe Kaihautū Pūtau. 2020;27(1):41–53.e6. PMID:31862381
• 2. McInnes IB, Byers NL, et al. "Whakatauritenga o baricitinib, upadacitinib, me tofacitinib takawaenga ture o cytokine tohu i roto i subpopulations leukocyte tangata." Arthritis Res Ther. 2019 Akuhata 2;21(1):183. PMID:31375130
• 3. Liu S, Verma M, et al. "Atete pūtaiaki o te ara rererangi momo 2 pūtau lymphoid taketake i tūroro ki te huango nui: Te mahi o te thymic stromal lymphopoietin."J Allergy Clin Immunol. 2018 Hanuere;141(1):257-268.e6. PMID:28433687
• 4. Zheng, Lufeng, et al. "Ko te 3' UTR o te pseudogene CYP4Z2P e whakatairanga ana i te angiogenesis pukupuku i roto i te mate pukupuku o te uma ma te mahi hei ceRNA mo CYP4Z1." Te rangahau me te maimoatanga mate pukupuku uma (2015): 1-14. PMID:25701119

Whakaahuatanga

Ko te Tofacitinib citrate he kaitautoko JAK1 / 2/3 e waatea ana me nga IC50s o 1, 20, me te 112 nM, ia. Ko te Tofacitinib citrate he mahi antibacterial, antifungal me te antiviral.

Rokiroki

4°C, tiaki i te marama

*I roto i te whakarewa: -80°C, 6 marama; -20°C, 1 marama (tiaki i te marama)

Hanganga matū

Raraunga Koiora e Pa ana

Raraunga Koiora e Pa ana

Raraunga Koiora e Pa ana

Raraunga Koiora e Pa ana

Raraunga Koiora e Pa ana