Ko Vericiguat hepyrazolopyridineara5-fluoro-1H-pyrazolo[3,4-b]pyridinei whakakapihia te hauwai amino i te waahi 1 e te roopu 2-fluorobenzyl me tehauwaii te waahi 3 kua whakakapihia e te roopu 4,6-diamino-5-[(methoxycarbonyl)amino]pyrimidin-2-yl.He wairewaguanylatecyclase stimulator e whakamahia ana mo te maimoatanga o te ngoikore o te ngakau.He mahi hei whakarewaguanylatecyclase activator, he kaihoko vasodilator me tetahi kaihoko antihypertensive.Heaminopyrimidine, apyrazolopyridine, he hākawa carbamate me te pūhui organofluorine.

Kei te tirotirohia a Vericiguat i roto i te whakamatautau haumanu NCT02861534 (He Akoranga mo te Vericiguat i roto i nga Kaiwhaiwhai Ki te Haangai Ngakau Ki te Hautanga Whakahekea Whakahekea (HFrEF) (MK-1242-001)).

Ko Vericiguat he WairewaGuanylateWhakaoho Hukarere.Ko te tikanga o te mahi a vericiguat he rite aGuanylateWhakaoho Hukarere.

Ko te Vericiguat he rongoa e whakamahia ana ki te whakahaere me te rongoa i te ngoikore o te ngakau me te iti o te hautanga ejection (HFrEF).He pai mo te ngoikore o te ngakau kino, te ngoikore o te ngakau kua heke tata nei.Kare a Vericiguat e whakaroa i te oranga engari ka aukati i te whakahokinga mai.Ko tenei ngohe e whakaatu ana i nga tohu, te tikanga mahi, te horopeta, me te ahua o te whakahaere a te roopu ngaio, nga paanga kino, nga aukati, me te maha o nga whakamatautau hei tautoko i nga taunakitanga o te whaihua o te tarukino i roto i te HFrEF.