Whakaahuatanga

Ko Rosuvastatin Calcium (BANM, JAN, USAN) e mohiotia ana ko Rosuvastatin i te US. me te whakataetae HMG-CoA reductase inhibitor me te IC50 o 11 nM[1]. Ko te Rosuvastatin Calcium ka kaha te aukati i te ira eter-a-go-go-tangata (hERG) naianei me te IC50 o te 195 nM, ka whakaroa i te repolarization o te ngakau, na reira ka roa te roanga mahi (APDs) me te whakatika i nga waahi QT (QTc) [2]. Ko Rosuvastatin Calcium he whakaheke i te whakaaturanga o te hERG pakeke me te pahekoheko o te pūmua wiri wera 70 (Hsp70) me te pūmua hERG. Ko te Rosuvastatin Calcium he tino whai hua ki te whakaheke i te lipoprotein iti (LDL) cholesterol, triglycerides, me nga taumata pūmua C-reactive[3].

Ko etahi atu korero mo nga tikanga whakaingoa tarukino: Nga Ingoa Kai-kore o te Ao.

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I roto i te US, ko Rosuvastatin (rosuvastatin systemic) he mema o te raau taero statins ka whakamahia ki te hamani Atherosclerosis, Cholesterol High, Cholesterol High - Heterozygous Whanau, Cholesterol High - Familial Homozygous, Hyperlipoproteinemia, Hyperlipoproteinemia Momo IIa - Momo LDL teitei, Hyperlipoproteinemia. IIb - Whakanuia te LDL VLDL, Hyperlipoproteinemia Momo III - Whakanuia te beta-VLDL IDL, Hyperlipoproteinemia Momo IV - Whakanuia te VLDL, Hypertriglyceridemia me te Aukati i te mate ngakau.

Papamuri

He aukati, he aukati whakataetae mo te HMG-CoA reductase, he antilipemic hoki.

Rokiroki

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