Papamuri

Ko te Atorvastatin Calcium he aukati kaha o te HMG-CoA reductase me te uara IC50 o te 150 nM[1].
Ko te HMG-CoA reductase te whākōkī matua o te ara mevalonate e whakaputa cholesterol.Ko te HMG-CoA te whākōkī whakaheke reiti, ā, he mea nui mō te whakaheke i ngā taumata cholesterol toto.Ko te HMG-CoA reductase kei roto i te reticulum endoplasmic, e waru nga rohe whakawhiti.Ka taea e nga aukati o te HMG-CoA reductase te whakakorikori i te LDL (te iti kiato lipoprotein) te whakaputa korero i roto i te ate.Ka arahi ki te whakanui ake i nga taumata catabolism o te LDL plasma me te whakaheke i te kukū o te cholesterol plasma he tohu nui mo te atherosclerosis.Ko te HMG-CoA reductase he mahi nui ki te whakahiato cholesterol.Ko HMG-CoA te whainga mo nga raau taero whakaheke cholesterol.Ko te HMG-CoA reductase he whākōkī nui mō te whanaketanga.Ko te ngohe o te HMG-CoA reductase e pa ana ki nga ngoikoretanga o te heke o nga pūtau iroriki.Ko te aukati i tana mahi ka arahi i te whakaheke toto i roto i te cerebral[1].
Ko te Atorvastatin he aukati HMG-CoA reductase me te uara IC50 o te 154 nM.He whai hua ki te rongoa i etahi dyslipidemias me te hypercholesterolemia[1].Ko te maimoatanga o te Atorvastatin i te 40 mg ka whakaheke i te cholesterol katoa o te 40% i muri i te 40 ra.[1]Ka whakamahia ano ki te rongoa i nga turoro mate pukupuku, mate whiu ranei me nga taumata cholesterol noa.[2]Ka whakahekehia ano hoki e te Atorvastatin te apheresis o te lipoprotein kiato iti i roto i nga turoro ma te akiaki i nga korero a nga kaiwhiwhi LDL.
Ka whakakorikoria ki te maha o nga metabolites he mea nui mo te painga o nga mahi rongoa a CYP3A4 (cytochrome P450 3A4).[3]
Tohutoro:
[1].van Dam M, Zwart M, de Beer F, Smelt AH, Prins MH, Trip MD, Havekes LM, Lansberg PJ, Kastelein JJ: Te whai hua mo te wa roa me te haumaru o te atorvastatin i roto i te maimoatanga o te momo III kino me te dyslipidemia whakakotahi.Ngakau 2002, 88(3):234-238.
[2].Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT et al: Te aukati i nga huihuinga coronary me te whiu me te atorvastatin i nga turoro hypertensive he toharite, he iti ake ranei. -te tohenga o te cholesterol, i roto i te Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): he whakawakanga whakahaere matapōkeretia.Lancet 2003, 361(9364):1149-1158.
[3].Lennernas H: pharmacokinetics haumanu o te atorvastatin.Clin Pharmacokinet 2003, 42 (13): 1141-1160.

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