Whakaahuatanga

Ko te konupūmā Pitavastatin (NK-104 hemicalcium) he kaha te aukati hydroxymethylglutaryl-CoA (HMG-CoA) reductase.Ko te konupūmā Pitavastatin (NK-104 hemicalcium) ka aukati i te whakahiato cholesterol mai i te waikawa acetic me te IC50 o te 5.8 nM i roto i nga pūtau HepG2.Ko te Pitavastatin Calcium he kaikawe whakangao i te hepatocyte iti-kiato lipoprotein-cholesterol (LDL-C).Nga mahi aukati mate pukupuku.

Papamuri

Ko te konupūmā Pitavastatin he aukati whakataetae o te enzyme HMGCR (HMG-CoA reductase) ka puta te whakahekenga o te kohinga LDL cholesterol.Ko nga rangahau rereke e whakaatu ana ka taea e te pitavastatin te whakakore i te hanga hāora i roto i nga pūtau endothelial ma te aukati i te NADPH oxidase.I tua atu, ka whakahekehia e te pitavastatin te whakaputanga o te eNOS mRNA me te whakanui ake i te whakautu KORE e ti'aturihia ana e te acetylcholine me te calcium ionophore, A23187.I tua atu, ko te pitavastatin te aukati i te whakahaerenga o nga hongere pāhare pāporo-whakahohe konupūmā ma te whakaheke i nga taumata cholesterol i roto i nga pūtau.

Rokiroki

4°C, tiaki i te marama

*I te whakarewa: -80°C, 6 marama;-20°C, 1 marama (tiaki i te marama)

Hanganga matū

Raraunga Koiora e Pa ana