Dabigatran Etexilate Mesylate
Whakaahuatanga
Ko te Dabigatran etexilate mesylate (BIBR 1048MS) he rongoa a-waha o Dabigatran. Ko te Dabigatran etexilate mesylate he hua anticoagulant ka whakamahia mo te aukati i te venousthromboembolism me te whiu na te fibrillation atrial.
Papamuri
Whakaahuatanga: IC50 Uara: 4.5nM (Ki); 10nM(Thrombin-induced platelet aggregation) [1] Ko te Dabigatran he kaitahuri thrombin tika (DTI) ka taea te huri me te whiriwhiri, e whai ana i te whakawhanaketanga haumanu matatau hei rongoa mo te waha, ko te dabigatran etexilate. i roto i te vitro: Dabigatran tīpakohia me te whakahuri i te thrombin tangata (Ki: 4.5 nM) tae atu ki te thrombin-induced platelet aggregation (IC(50): 10 nM), i te kore e whakaatu ana i te awenga aukati i runga i etahi atu raau taero-whakaongaonga platelet.Thrombin generation in platelet -Poor plasma (PPP), i inehia na te mea ka aukati te kaha o te thrombin endogenous (ETP) i runga i te kukū-whakaaro. (IC(50): 0.56 microM). I whakaatu a Dabigatran i nga paanga anticoagulant e whakawhirinaki ana ki te kukū i roto i nga momo momo i roto i te vitro, ka ruarua te wa o te thromboplastin waahanga (aPTT), te wa prothrombin (PT) me te wa e kii ana i te ecarin (ECT) i roto i te PPP tangata i te kuhanga o te 0.23, 0.83 me te 0.18 microM, ia. 1]. in vivo: I whakaroahia e Dabigatran te horopeta aPTT-i muri i te whakahaerenga i roto i nga kiore (0.3, 1 me te 3 mg / kg) me nga makimaki rhesus (0.15, 0.3 me te 0.6 mg / kg). I kitea nga paanga anticoagulant inenga me te wa e whakawhirinaki ana ki te dabigatran etexilate i tukuna ma te waha ki nga kiore mohio (10, 20 me te 50 mg/kg) me nga makimaki rhesus (1, 2.5, 5 mg/kg ranei), me nga paanga teitei ka kitea i waenga i te 30 me te 120 min i muri i te whakahaere, ia [1]. Ko nga turoro e rongoahia ana e te dabigatran etexilate he iti ake nga whiu ischemic (3.74 dabigatran etexilate vs 3.97 warfarin) me te iti ake o te whakakotahitanga o nga toto toto me nga whiu haemorrhagic (0.43 dabigatran etexilate vs 0.99 warfarin) mo ia [120 tau manawanui]. Te whakamatautau haumanu: He Aromātai o te Pharmacokinetics me te Pharmacodynamics o Oral Dabigatran Etexilate i roto i nga turoro Hemodialysis. Wāhanga1
Rokiroki
| Paura | -20°C | 3 tau |
| 4°C | 2 tau | |
| I roto i te whakarewa | -80°C | 6 marama |
| -20°C | 1 marama |
Whakamatautau Haumanu
| Nama NCT | Kaitautoko | Tikanga | Rā Tīmata | Wāhanga |
| NCT02170792 | Boehringer Ingelheim | Hauora | Hui-tanguru 2001 | Wāhanga 1 |
| NCT02170974 | Boehringer Ingelheim | Hauora | Hōngongoi 2004 | Wāhanga 1 |
| NCT02170831 | Boehringer Ingelheim | Hauora | Haratua 1999 | Wāhanga 1 |
| NCT02170805 | Boehringer Ingelheim | Hauora | Paenga-whāwhā 2001 | Wāhanga 1 |
| NCT02170610 | Boehringer Ingelheim | Hauora | Poutū-te-rangi 2002 | Wāhanga 1 |
| NCT02170909 | Boehringer Ingelheim | Hauora | Hakihea 2004 | Wāhanga 1 |
| NCT02171000 | Boehringer Ingelheim | Hauora | Paenga-whāwhā 2005 | Wāhanga 1 |
| NCT02170844 | Boehringer Ingelheim | Hauora | Pipiri 2004 | Wāhanga 1 |
| NCT02170584 | Boehringer Ingelheim | Hauora | Hanuere 2001 | Wāhanga 1 |
| NCT02170935 | Boehringer Ingelheim | Ko te Thromboembolism | Paenga-whāwhā 2002 | Wāhanga 2 |
| NCT02170636 | Boehringer Ingelheim | Hauora | Hanuere 2002 | Wāhanga 1 |
| NCT02170766 | Boehringer Ingelheim | Hauora | Oketopa 2000 | Wāhanga 1 |
| NCT02171442 | Boehringer Ingelheim | Hauora | Paenga-whāwhā 2002 | Wāhanga 1 |
| NCT02170896 | Boehringer Ingelheim | Hauora | Oketopa 2001 | Wāhanga 1 |
| NCT02173730 | Boehringer Ingelheim | Hauora | Noema 2002 | Wāhanga 1 |
| NCT02170623 | Boehringer Ingelheim | Hauora | Hui-tanguru 2002 | Wāhanga 1 |
| NCT02170116 | Boehringer Ingelheim | Hauora | Noema 1998 | Wāhanga 1 |
| NCT02170597 | Boehringer Ingelheim | Hauora | Akuhata 2003 | Wāhanga 1 |
| NCT01225822 | Boehringer Ingelheim | Ko te Thromboembolism | Noema 2002 | Wāhanga 2 |
| NCT02170701 | Boehringer Ingelheim | Ko te Thromboembolism | Oketopa 2000 | Wāhanga 2 |
| NCT02170740 | Boehringer Ingelheim | Hauora | Noema 1999 | Wāhanga 1 |
| NCT02170922 | Boehringer Ingelheim | Hauora | Hōngongoi 1999 | Wāhanga 1 |
Hanganga matū
Tono18Ko nga kaupapa Aromātai Tauritenga Kounga kua whakaaetia4, a6kei te whakamanahia nga kaupapa.
Ko te punaha whakahaere kounga teitei o te ao kua whakatakoto he turanga pakari mo nga hoko.
Ko te tirotiro i te kounga ka haere i roto i te huringa ora katoa o te hua ki te whakarite i te kounga me te hua rongoa.
Ko te roopu Whakahaere Whakahaere Ngaio e tautoko ana i nga tono kounga i te wa o te tono me te rehitatanga.
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