Papamuri

Ko te Canagliflozin he mea hou, kaha, me te tino kowhiria te konutai konutai glucose co-transporter (SGLT) 2 aukati [1]. Kua whakaatuhia ka taea e Canagliflozin te whakanui ake i te whakahekenga o te huka ki roto i te mimi ma te whakaheke i te paepae hukahuka o te whatukuhu me te whakaheke i te whakauru ano o te huka toto.

Kua whakaatuhia te Canagliflozin ki te aukati i te Na + -mediated 14C-AMG intakes i CHO-hSGLT2, CHO-rat SGLT2 me CHO-kiore SGLT2 me nga uara IC50 o 4.4, 3.7 me 2.0 nM, ia [1].

Ko te Canagliflozin kua korerohia he whakaheke i nga taumata huka toto (BG) i runga i te horopeta i roto i nga kiore db/db me nga kiore Zucker mate huka (ZDF) kiore. Hei taapiri, kua whakaatuhia e te canagliflozin te whakaheke i te tauwehenga whakawhiti manawa, me te taumaha tinana i roto i nga kiore DIO me nga kiore ZDF [1].

Ka taea te tango i te Canagliflozin ma te waha.

Tohutoro:
[1] Liang Y1, Arakawa K, Ueta K, Matsushita Y, Kuriyama C Martin T, Du F, Liu Y, Xu J, Conway B, Conway J, Polidori D, Ways K, Demarest K. Te paanga o te canagliflozin ki te paepae renal mo te huka, te glycemia, me te taumaha tinana i roto i nga tauira kararehe noa me te mate huka. PLoS Kotahi. 2012;7(2):e30555
[2] Sarnoski-Brocavich S, Hilas O. Canagliflozin (Invokana), he Agent Oral Novel mo te mate huka Momo-2. P T. 2013 Noema;38(11):656-66

Tohunga Hua

Bahia Abbas Moussa, Marianne Alphonse Mahrouse, et al. "Ko nga tikanga whakatau rereke mo te whakahaere i te hihinga īnaki: Te tono mo te whakatau i nga raau taero hypoglycemic hou i hangaia i roto i o raatau momo inenga rongoa." Spectrochimica Acta Wāhanga A: Molecular and Biomolecular Spectroscopy Kei runga ipurangi 20 Pipiri 2018.

Hanganga matū