Ko Vericiguat hepyrazolopyridineara5-fluoro-1H-pyrazolo[3,4-b]pyridinei whakakapihia te hauwai amino i te waahi 1 e te roopu 2-fluorobenzyl me tehauwaii te waahi 3 kua whakakapihia e te roopu 4,6-diamino-5-[(methoxycarbonyl)amino]pyrimidin-2-yl. He wairewaguanylatecyclase stimulator e whakamahia ana mo te maimoatanga o te ngoikore o te ngakau. He mahi hei whakarewaguanylatecyclase activator, he kaihoko vasodilator me tetahi kaihoko antihypertensive. He heaminopyrimidine, apyrazolopyridine, he hākawa carbamate me te pūhui organofluorine.

Kei te tirotirohia a Vericiguat i roto i te whakamatautau haumanu NCT02861534 (He Akoranga mo te Vericiguat i roto i nga Kaiuru me te Haangai Ngakau Ki te Hautanga Whakahekea Whakahekea (HFrEF) (MK-1242-001)).

Ko te Vericiguat he WairewaGuanylateWhakaoho Hukarere. Ko te tikanga o te mahi a vericiguat he rite aGuanylateWhakaoho Hukarere.

Ko te Vericiguat he rongoa e whakamahia ana ki te whakahaere me te rongoa i te ngoikore o te ngakau me te hautanga whakaheke whakaheke (HFrEF). He pai mo te ngoikore o te ngakau kino, te ngoikore o te ngakau kua heke iho nei. Kare a Vericiguat e whakaroa i te oranga engari ka aukati i te whakahokinga mai. Ko tenei ngohe e whakaatu ana i nga tohu, te tikanga o te mahi, te horopeta, me te ahua o te whakahaere a te roopu mahi, nga paanga kino, te aukati, me te maha o nga whakamatautau hei tautoko i nga taunakitanga o te whaihua o te tarukino i roto i te HFrEF.