Crisaborole

Whakaahuatanga Poto:

Ingoa API Tohutohu Kaihanga hou Te Ra Whakamutunga Patent(Te US)
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Taipitopito Hua

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WHAKAMAHI HUA

Ko Crisaborole he mema o te karaehe o te benzoxaboroles he 5-hydroxy-1,3-dihydro-2,1-benzoxaborole kei roto te phenolic.hauwaikua whakakapihia e te roopu 4-cyanophenyl. He aukati phosphodiesterase 4 e whakamahia ana mo te maimoatanga o te mate ngawari ki te ngawari o te mate o nga tamariki me nga pakeke. He mahi hei aukati phosphodiesterase IV, heantisoriaticme te tarukino anti-inflammatory kore-steroidal. He benzoxaborole, he ether kakara me te nitrile.

He pūrākau a Crisaboroleoxaborolei whakaaetia e te FDA i te Hakihea 14, 2016 hei Eucrisa, he maimoatanga mo te mate mo te ngawari me te ngawari o te mate pukupuku. Ko tenei kaihoko kore-steroidal he kaha ki te whakapai ake i te kaha o te mate, te whakaiti i te mate o te mate me te whakaiti i nga tohu me nga tohu i roto i nga turoro 2 tau me te pakeke ake. Ka whakaitihia te mumura o te rohe i roto i te kiri me te aukati i te kaha ake o te mate me te tohu haumaru pai. Kei roto i tona hanganga aboronngota, e whakahaere ana i te urunga o te kiri me te here ki te pokapū bimetal o te phosphodiesterase 4 enzyme. I tenei wa kei te whakawhanakehia hei maimoatanga kaupapa mo te psoriasis.

Ko te Crisaborole he Phosphodiesterase 4 Inhibitor. Ko te tikanga o te mahi o te crisaborole ko te Phosphodiesterase 4 Inhibitor.

Tiwhikete

2018 GMP-2
原料药GMP证书201811(captopril, thalidomide etc)
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FDA-EIR-Reta-201901

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