Bictegravir 1611493-60-7
Whakaahuatanga
Ko Bictegravir he pukapuka, he aukati kaha o te whakauru HIV-1 me te IC50 o te 7.5 nM.
In Vitro
Ko te Bictegravir (BIC) te aukati i te mahi whakawhiti whenu me te IC50 o 7.5± 0.3 nM.E pa ana ki tana aukati i nga mahi whakawhiti whenu, ko te Bictegravir he aukati ngoikore o te 3'- mahi tukatuka o HIV-1 IN, me te IC50 o 241±51 nM.Ka whakanui a Bictegravir i te kohinga o nga porowhita 2-LTR ~5-fold e pa ana ki te mana whakahiahia me te whakaiti i te nui o nga hua whakauru pono i roto i nga pūtau pangia e te 100-fold.Ka kaha te aukati a Bictegravir i te tukuruatanga HIV-1 i roto i nga pūtau MT-2 me MT-4 me nga EC50 o te 1.5 me te 2.4 nM, ia.Ko te Bictegravir e whakaatu ana i nga paanga antiviral kaha i roto i nga lymphocytes CD4+ T tuatahi me nga macrophages i ahu mai i te monocyte, me nga EC50 o te 1.5±0.3 nM me te 6.6±4.1 nM, ia, e rite ana ki nga uara e whiwhi ana i nga rarangi T-cell[1].
Kare ano a MCE i whakapumau takitahi i te tika o enei tikanga.He tohutoro anake.
| Nama NCT | Kaitautoko | Tikanga | Rā Tīmata | Wāhanga |
| NCT03998176 | Te Whare Wananga o Nebraska|Gilead Sciences | HIV-1-mate | Oketopa 9, 2019 | Wāhanga 4 |
| NCT03789968 | Te Whare Wananga o Thomas Jefferson|Te Whare Wananga o Maryland, College Park|Te Whare Wananga o Indiana|Te Whare Wananga o te Whare Wananga o Brooklyn|Te Whare Wananga o Illinois ki Chicago|Te Whare Wananga o Nova Southeastern|Te Whare Wananga o California, San Francisco | HIV+AIDS | Mahuru 1, 2019 | |
| NCT04249037 | Te Whare Wananga o Colorado, Denver|Gilead Sciences | HIV+AIDS | Maehe 1, 2020 | Kaore e tika ana |
| NCT04132674 | Te Whare Mate Infectious Diseases Vancouver | Human Immunodeficiency Virus I Infection|Whakamahi Taakaro | Noema 26, 2018 | Wāhanga 4 |
| NCT04054089 | Cristina Mussini|Te Whare Wananga o Modena me Reggio Emilia | Nga mate HIV | Mahuru 2019 | Wāhanga 4 |
| NCT04155554 | Azienda Ospedaliera Universitaria Senese|Te Whare Wananga Katorika o te Ngakau Tapu|Ospedale Policlinico San Martino|Azienda Ospedaliera San Paolo|Ospedale Amedeo di Savoia | HIV-1-mate | Hanuere 29, 2020 | Wāhanga 3 |
| NCT02275065 | Pūtaiao Gileada | Te mate HIV-1 | Whiringa-ā-nuku 2014 | Wāhanga 1 |
| NCT03711253 | Te Whare Wananga o Southern California | Te mate HIV whakapeka | Oketopa 14, 2019 | Wāhanga 4 |
| NCT02400307 | Pūtaiao Gileada | HIV | Paenga-whāwhā 17, 2015 | Wāhanga 1 |
| NCT03499483 | Hauora Hapori Fenway | Te aukati HIV | Hanuere 24, 2019 | Wāhanga 4 |
| NCT03502005 | Midland Research Group, Inc.|Gilead Sciences | Te Waarere Whakamatea Tangata | Maehe 1, 2018 | Wāhanga 4 |
Hanganga matū
Tono18Ko nga kaupapa Aromātai Tauritenga Kounga kua whakaaetia4, a6kei te whakamanahia nga kaupapa.
Ko te punaha whakahaere kounga teitei o te ao kua whakatakoto he turanga pakari mo nga hoko.
Ko te tirotiro i te kounga ka haere i roto i te huringa ora katoa o te hua ki te whakarite i te kounga me te hua rongoa.
Ko te roopu Whakahaere Whakahaere Ngaio e tautoko ana i nga hiahia kounga i te wa o te tono me te rehitatanga.
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