Papamuri

Ko te Atorvastatin Calcium he aukati kaha o te HMG-CoA reductase me te uara IC50 o te 150 nM[1].
Ko te HMG-CoA reductase te whākōkī matua o te ara mevalonate e whakaputa cholesterol. Ko te HMG-CoA te whākōkī whakawhāiti reiti, ā, he mea nui mō te whakaheke i ngā taumata cholesterol toto. Ko te HMG-CoA reductase kei roto i te reticulum endoplasmic, e waru nga rohe transmembrane kei roto. Ka taea e nga aukati o te HMG-CoA reductase te whakakorikori i te LDL (te iti kiato lipoprotein) te whakaputa korero i roto i te ate. Ka arahi ki te whakanui ake i nga taumata catabolism o te LDL plasma me te whakaheke i te kukū o te cholesterol plasma he tohu nui mo te atherosclerosis. Ko te HMG-CoA reductase he mahi nui ki te whakahiato cholesterol. Ko te HMG-CoA te whainga mo nga raau taero whakaheke cholesterol. Ko te HMG-CoA reductase he whākōkī nui mō te whanaketanga. Ko te ngohe o te HMG-CoA reductase e pa ana ki nga ngoikoretanga o te heke o nga pūtau iroriki. Ko te aukati i tana mahi ka arahi i te whakaheke toto i roto i te cerebral[1].
Ko te Atorvastatin he aukati HMG-CoA reductase me te uara IC50 o te 154 nM. He whai hua ki te rongoa i etahi dyslipidemia me te hypercholesterolemia[1]. Ko te maimoatanga o te Atorvastatin i te 40 mg ka whakaheke i te cholesterol katoa o te 40% i muri i te 40 ra.[1] Ka whakamahia ano ki te rongoa i nga turoro mate pukupuku, mate whiu ranei me nga taumata cholesterol noa.[2] Ka whakahekehia e te Atorvastatin te apheresis lipoprotein iti i roto i nga turoro ma te whakatairanga i nga korero a nga kaiwhiwhi LDL.
Ka whakakorikoria ki te maha o nga metabolites he mea nui mo te painga o nga mahi rongoa a CYP3A4 (cytochrome P450 3A4).[3]
Tohutoro:
[1]. van Dam M, Zwart M, de Beer F, Smelt AH, Prins MH, Trip MD, Havekes LM, Lansberg PJ, Kastelein JJ: Te whai hua mo te wa roa me te haumaru o te atorvastatin i roto i te maimoatanga o te momo III kino me te dyslipidemia whakakotahi. Ngakau 2002, 88(3):234-238.
[2]. Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT et al: Te aukati i nga huihuinga coronary me te whiu me te atorvastatin i nga turoro hypertensive he toharite, he iti ake ranei. -te nui o te cholesterol, i te Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre matapōkeretia te whakamātautau whakahaere. Lancet 2003, 361(9364):1149-1158.
[3]. Lennernas H: pharmacokinetics haumanu o te atorvastatin. Clin Pharmacokinet 2003, 42 (13): 1141-1160.

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