Whakaahuatanga

Ko te Hydrochlorothiazide (HCTZ), he rongoa diuretic kaha o te roopu thiazide, ka aukati i te hurihanga TGF-β/ ara tohu tohu Smad.Ko te Hydrochlorothiazide he whakangawari totika toto na roto i te whakatuwheratanga o te hongere konupūmā-whakahohe pāhare pāporo (KCA).Ko te Hydrochlorothiazide te whakapai ake i te mahi ngakau, te whakaheke i te fibrosis me te whai hua antihypertensive.

Papamuri

Ko te Hydrochlorothiazide he rongoa diuretic o te roopu thiazide.

In Vitro

Ko te Hydrochlorothiazide no te roopu thiazide o nga diuretics.Ka whakahekehia te toto ma te mahi i runga i nga whatukuhu ki te whakaheke i te konutai (Na) reabsorption i roto i te ngongo pukoro.Ko te waahi nui o te mahi i roto i te nephron ka puta i runga i te hikohiko Na+-Cl-co-transporter na roto i te whakataetae mo te waahi chloride i runga i te kaikawe.Ma te whakararu i te kawe Na i roto i te ngongo ngongo, ka whakapakeke te hydrochlorothiazide i te natriuresis me te ngaronga wai.Ko nga Thiazides te whakanui ake i te reabsorption o te konupūmā i roto i tenei waahanga i roto i nga tikanga kaore e pa ana ki te kawe konutai.I tua atu, na etahi atu tikanga, e whakaponohia ana ko te Hydrochlorothiazide te whakaheke i te aukati vascular peripheral.

Ko te Hydrochlorothiazide (HCTZ; te tango-a-waha; 12.5 mg/kg/d; 8 wiki) kua pai ake te mahi o te ngakau, kua heke te fibrosis interstitial cardiac me te hautanga rōrahi collagen, kua heke te whakaaturanga o AT1, TGF-β me Smad2 i roto i nga kopa ngakau i roto i nga kiore tane pakeke Sprague Dawley.Hei taapiri, ko te hydrochlorothiazide te whakaheke i te plasma angiotensin II me nga taumata aldosterone.I tua atu, ka whakakorehia e te hydrochlorothiazide te angiotensin II-induced TGF-β1 me te korero pūmua Smad2 i roto i nga fibroblasts ventricular neonatal kiore.

Hanganga matū