Whakaahuatanga

Ko te Hydrochlorothiazide (HCTZ), he rongoa diuretic kaha-waha o te karaehe thiazide, ka aukati i te hurihanga TGF-β/ ara tohu Smad. Ko te Hydrochlorothiazide he whakangawari totika toto ma te whakatuwheratanga o te hongere konupūmā-whakahohe pāhare pāporo (KCA). Ko te Hydrochlorothiazide te whakapai ake i te mahi ngakau, te whakaheke i te fibrosis me te whai hua antihypertensive.

Papamuri

Ko te Hydrochlorothiazide he rongoa diuretic o te roopu thiazide.

In Vitro

Ko te Hydrochlorothiazide no te roopu thiazide o nga diuretics. Ka whakahekehia te toto ma te mahi i runga i nga whatukuhu ki te whakaheke i te konutai (Na) reabsorption i roto i te ngongo pukoro. Ko te waahi nui o te mahi i roto i te nephron ka puta mai i runga i te hikohiko Na+-Cl-co-transporter na roto i te whakataetae mo te waahi chloride i runga i te kaikawe. Ma te whakararu i te kawe Na i roto i te ngongo ngongo, ka whakapakeke te hydrochlorothiazide i te natriuresis me te mate wai. Ko te Thiazides te whakanui ake i te reabsorption o te konupūmā i roto i tenei waahanga kaore i te hono atu ki te kawe konutai. Hei taapiri, na etahi atu tikanga, ka whakaponohia te Hydrochlorothiazide ki te whakaheke i te aukati vascular peripheral.

Ko te Hydrochlorothiazide (HCTZ; te waha-a-waha; 12.5 mg/kg/d; 8 wiki) kua pai ake te mahi o te ngakau, kua whakahekehia te fibrosis interstitial cardiac me te hautanga rōrahi collagen, kua heke te whakaaturanga o AT1, TGF-β me Smad2 i roto i nga kopa ngakau i roto i nga kiore tane pakeke Sprague Dawley. Hei taapiri, ko te hydrochlorothiazide te whakaheke i te plasma angiotensin II me nga taumata aldosterone. I tua atu, ka whakakorehia e te hydrochlorothiazide te angiotensin II-induced TGF-β1 me Smad2 whakaaturanga pūmua i roto i te neonatal kiore ventricular fibroblasts.

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